Prevention of such negativeconsequences is the most important scientific-practical task.The CRH involvement in the formation mechanisms of sucha variety of pathologies, reflecting the stress effects on brainfunctioning, suggests that the extrahypothalamic CRH systemmay be a potential molecular target for preventing the negative consequences of stress with a high therapeutic potential,because сhronic elevated CRH concentrations have been foundin the cerebrospinal fluid of patients with mood disorders,depression, and post-traumatic stress disorder. Here, CRH is linked to major depressive disorder.