Inrodents, increased CRH expression in the brain induces ananxiogenic behavioral phenotype (Van Gaalen et al., 2002),while suppression of CRH expression has an anxiolytic effectin basal and stress-induced anxiety (Henckens et al., 2016).CRH levels are elevated in the brains of people suffering fromstress-related mental illnesses such as major depressive disorder and post-traumatic stress disorder (PTSD) (Rasmusson,Pineles, 2018) and, in some cases, normalize after treatmentwith antidepressants (Inda et al., 2017). The gene discussed is CRH; the disease is major depressive disorder.