Repetitive CRHR activation in BNST, caused anxiety, increases the genes expression of the serotonergic systemin DR, including Tph2 (a gene of a key serotonin synthesisenzyme) and Slc6a4 (a gene encoding a serotonin transporter(SERT)) (Donner et al., 2020). This evidence concerns the gene CRHR1 and Anxiety.