The phosphoinositide 3-kinases (PI3k)/phosphatase and tensin homolog (PTEN)/protein kinase B (Akt)/mammalian/mechanistic target of rapamycin complex 1 (mTORC1) is another key pathway activated in pancreatic adenocarcinomas and the latter pathway is associated with KRAS. The gene discussed is AKT1; the disease is pancreatic adenocarcinoma.