ABCG2 and cancer: In a recent study on Manuka honey anticancer effect on HCT-116's cancer stem cells (CSCs), the size of culture spheroids was reduced and there was also induction of apoptosis, decreased expression of mRNA of one ABC transporter (ABCG2) and down modulation of mRNA expression of the receptor membranes of Wnt/β-catenin pathway because of the polyphenolic content of the honey extracts (Cianciosi et al., 2020).