VWF and diabetes mellitus: Therefore, Flebotrofine® could be a useful support to the traditional therapy to prevent the long-term complications of diabetes; although to corroborate these conclusions, other studies are necessary to evaluate other markers of endothelial damage, such as NO, prostacyclin (PGI2), thromboxane A2 (TXA2), factor VIII (FVIII), von Willebrand factor (vWF), and the vascular tone.