NFKB1 and liver disorder: Several studies have shown the probiotic benefits on various hepatic diseases through different pathways such as inhibiting TLR4-mediated endotoxin and TNF-α production [54], suppressing the MAPK and NF-κB signaling pathways [55], and upregulating nuclear factor erythroid 2-related factor 2 and its downstream antioxidative genes [56].