BNIP3 is an apoptosis-inducing protein, Diwan et al. (87) and Dorn et al. (88) reported that BNIP3 ablation in unstressed mice reveals no essential function, but BNIP3 specific knockout mice suffered reduced apoptosis and cardiac remodelling after myocardial infarction. The gene discussed is BNIP3; the disease is myocardial infarction.