Moreover, B cells in this dataset were predicted to be activated to plasma cells with the high expression level of Cr2 (encoding Cd21) and Ighm, and the upregulated genes of B cells were mainly enriched in the function of “immunoglobulin mediated immune response.” As for T cells, “natural killer cell activation” was upregulated with increased expression of Klrb1c and Il2rb in AAA pathogenesis. Here, IGHM is linked to triple-A syndrome.