DGAT2 and hyperinsulinemic hypoglycemia, familial, 4: Overexpression of DGAT2 in mouse liver causes significant hepatic steatosis as evidenced by increased hepatic TG levels but not insulin resistance (41), whereas in obese mice induced by high-fat diet or leptin-deficiency for 7 weeks, inhibition of DGAT2 with an optimized antisense oligonucleotide resulted in marked reduction in hepatic TG as well as blood TG, diacylglycerol, and free fatty acid levels (42).