Lee et al. (2019) demonstrated that PRDX6 induces effects of maintaining mitochondrial integrity and inhibits OS-induced Notch signaling, thereby reducing ROS production and lipid accumulation. They pointed out that PRDX6 mitophagy-mediated mechanisms offer endogenous protection against NAFLD (Lee et al., 2019). This evidence concerns the gene PRDX6 and metabolic dysfunction-associated steatotic liver disease.