HCC-derived exosomal circUHRF1 was found to upregulate the expression of the miR-449c-5p target gene TIM-3 in NK cells by combining with and degrading miR-449c5p, leading to the promotion of immune evasion and resistance to anti-PD1 immunotherapy in HCC (Zhang et al., 2020). The gene discussed is HAVCR2; the disease is hepatocellular carcinoma.