Data in CRC research also presented that CRC-derived exosomal circPACRGL stimulated CRC proliferation and metastasis, together with the differentiation of N1-N2 neutrophils via controlling miR-142-3p/miR-506-3p-TGF-β1 axis (Shang et al., 2020) and an exo-circRNA derivative, exosomal circ-133, from hypoxic cells transferred into normoxic cells and stimulated colorectal cancer metastasis through acting on miR-133a/GEF-H1/RhoA axis (Yang et al., 2020). The gene discussed is ARHGEF2; the disease is colorectal carcinoma.