NANOG and pachyonychia congenita: For instance, exosomal circ_0072083 promoted TMZ resistance via increasing Nanoghomeobox (NANOG) and administering miR-1252-5p mediated degradation and demethylation in glioma (Ding C. Y. et al., 2021) and additionally exosomal circ-XIAP stimulated DTX resistance of PC through the regulation of miR-1182/TPD52 axis further providing a promising therapeutic mark for PC chemotherapy (Zhang et al., 2021).