Integrin α5β1 is a well-known major receptor for FN1(Miroshnikova et al., 2017) and was demonstrated to bind to its receptor integrin α5β1 activating the PI3K/Akt signaling pathway, thus, promoting the progression of breast cancers (Veevers-Lowe et al., 2011). Here, AKT1 is linked to breast cancer.