Moreover, they observed in Fhit-negative lung cancer cells that the overexpression of FHIT protein, a molecule lost early in the majority of human tumors, avoided this subcellular relocalization thus restoring the sensitivity of cancer cells to paclitaxel-induced apoptosis, both in vitro and in vivo (Gaudio et al., 2013). The gene discussed is FHIT; the disease is lung cancer.