On the other hand, SPG11 and SPG7 are the most frequent AR HSP subtypes followed by SPG15 and SPG5 (Ruano et al., 2014; Tesson et al., 2015; Boutry et al., 2019b; Coarelli et al., 2019; Du, 2021). Here, SPG7 is linked to hereditary spastic paraplegia.