For example, proteins implicated in the cytoskeleton dynamics such as spastin, can participate in organellar shaping particularly in ER morphogenesis, or modulate the formation of lipid droplets (LD) which can be considered as the intersection of these pathways with lipid metabolism in the pathogenesis of HSP (Figure 3) (Papadopoulos et al., 2015; Tadepalle and Rugarli, 2021). This evidence concerns the gene SPAST and hereditary spastic paraplegia.