In 2019, the EAU prostate cancer guidelines update proposed that the risk of subsequent metastasis after prostate cancer surgery, as well as PCa CSD and overall mortality, can be determined by initial clinical and pathological factors (Tstage, ISUP grade) and PSA dynamics (PSA double time and PSA failure interval) to predict (44). The gene discussed is KLK3; the disease is posterior cortical atrophy.