Among top ten circRNAs significantly up-regulated in CHB compared to normal controls, circRNA has-circ-0004812 impairs IFN-induced immune response by sponging miR-1287-5p to regulate Follistatin-related protein (FSTL) 1 in chronic hepatitis B (62, 132). The gene discussed is IFNA1; the disease is chronic hepatitis B virus infection.