The further mechanism was that GAL and borneol provide a rational strategy for the construction of a functional nanosystem to reverse multidrug-resistant cancers by inhibiting the expression of ATP-binding cassette family proteins, inducing cell apoptosis through ROS-activated p53 phosphorylation, mitogen-activated protein kinase (MAPK), and protein kinase B (AKT) pathways. Here, AKT1 is linked to cancer.