AMPD3 and autosomal dominant polycystic kidney disease: Inhibiting AMPD3 by pentostatin, or cyclic dependent kinase 7 (CDK7), one of the controlled metabolic target genes, decreased cell proliferation and apoptosis in ADPKD cells and delayed disease progression in tamoxifen-inducible Pkd1 mice with slowly progressing ADPKD (126).