Ramalingam et al. found a higher methionine-S-adenosyl methionine (SAM) levels and methyltransferase-like 3 (Mettl3) upregulation in multiple ADPKD mouse models and that methionine-SAM supplementation or Mettl3 overexpression induced cyst growth (133). This evidence concerns the gene METTL3 and autosomal dominant polycystic kidney disease.