Since it has been observed that the kinetics of cyst formation after Pkd1 inactivation in mice is sensitive to the age, specifically between days 12 and 14 (98), a network analysis has been applied to transcriptomics data from 36 mutants and 34 controls kidneys in order to study the changes during the P12-P14 interval that have such a drastic modifier effect in ADPKD (99). Here, PKD1 is linked to autosomal dominant polycystic kidney disease.