Studies suggested that NLRP3 inflammasomes and related pyrogenic signaling molecules played an essential role in the progression of cardiovascular diseases (Supplementary Table S6) (Liu et al., 2013; Jeyabal et al., 2016; Zhou et al., 2016; Huang et al., 2017; Nazir et al., 2017; Zhang et al., 2018a; Yang et al., 2018b; Li et al., 2018; Yue et al., 2019; Ding et al., 2020; Li et al., 2020). The gene discussed is NLRP3; the disease is cardiovascular disorder.