Dai et al. used Illumina microarray technology to analyze the gene expression changes in primary human oral fibroblasts after infection with Kaposi’s sarcoma-associated herpes virus and found that a series of IFN-stimulated genes were upregulated, especially ISG15 and ISG20, which maintain the virus incubation period by regulating Kaposi’s sarcoma-associated herpes virus-specific microRNA (Dai et al., 2016). The gene discussed is ISG15; the disease is infection.