Another study, involving immunohistological comparison of a cohort of resected PDAC and adjacent pancreatic tissue, linked moderate to high levels of COL6A3 in PDAC tissue with negative prognostic factors, such as tumor differentiation, lymph node metastasis, perineural invasion, and microvascular invasion (Svoronos et al., 2020). This evidence concerns the gene COL6A3 and neoplasm.