Most of these drugs such as Axitinib, Bevacizumab and Nintedanib (Kindler et al., 2011) (Bill et al., 2015) (Crane et al., 2009), target VEGF and cause depletion of the tumor stroma followed by decreased tumor growth (Bergers, and Benjamin 2003). The gene discussed is VEGFA; the disease is neoplasm.