HNF4A and neoplasm: Treatment of human colon cancer cells, and mouse salivary gland cells with such compound did not only reduce the β-catenin/TCF7l2-mediated proliferation rate and self-renewal, but also induced the differentiation of tumor cells (Fang et al., 2016), making it a potential therapeutic target of the β-catenin-TCF/LEF-dependent tumors, among other tested drugs (reviewed in Jung and Park, 2020; Walcher et al., 2020; Zhang and Wang, 2020).