GSDME and cancer: Previous studies have extensively documented a molecular machinery involving epigenetic inactivation due to GSDME promoter hypermethylation in a range of human cancers (Akino et al., 2007; Kim et al., 2008a; Kim et al., 2008b; Yokomizo et al., 2012; Wang et al., 2013; Ibrahim et al., 2019; De Schutter et al., 2020).