HF was once reported as a positive control drug that showed modest interaction of −6.91 kcal/mol having a Ki value of 8.61 μM with unbound p53 but expressed significant inhibition (Ki = 3.88 μM) against p21Waf1/Cip1 with binding energy of −7.38 kcal/mol. This evidence concerns the gene TP53 and hydrops fetalis.