For example, 23 associations of SBS1-specific in seven cancer types, including the mutations in TP53 (p.R175H, p.R248Q, p.R273H, and p.R282W), and the truncated mutations of APC and CDKN2A in CRC CIN and HPV- HNSC respectively (Figure 3). Here, TP53 is linked to cervical squamous intraepithelial neoplasia.