GMPs slightly express PD-1 in the naïve state and the expression of PD-1 is induced in the context of the tumor or in response to several factors such as granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony growth factor (GM-CSF), and TLR4 agonist (Strauss et al., 2020). The gene discussed is PDCD1; the disease is neoplasm.