Further, in a study using Hox5 compound null alleles (Hoxa5+ ⁣/−; Hoxb5–/–; Hoxc5+ ⁣/−), mice present with an increased Th2 cells response and exacerbated lung tissue pathology in asthma models (Ptaschinski et al., 2017). Here, HOXC5 is linked to asthma.