The activation of Yap1, which is a transcriptional coactivator as well as a negative regulator of the Hippo pathway, and is involved in intervertebral disc degeneration (Chen et al., 2019), was mainly affected in nucleus pulposus cells from Chsy3-deficient mice (Wei et al., 2020). The gene discussed is CHSY3; the disease is Intervertebral disk degeneration.