In the TCGA BLCA cohort, significantly decreased expression of naive CD4+ T cells, CD4+ central memory T cells (CD4 + Tcm), and naive CD8+ T cells was observed in the high-risk subgroup, while the expression of CD8 T cells, CD8+ central memory T cells (CD8 + Tcm), Th2 cells, and macrophages M1 tended to be low in the low-risk subgroup. Here, CD4 is linked to bladder transitional cell carcinoma.