The possible mechanism underlying the regulatory effect of rSj-Cys on reducing atherosclerosis and atherosclerotic renal damage is that rSj-Cys stimulates Tregs and M2 macrophage polarization to produce regulatory cytokines IL-10 and TGF-β, thereby inhibiting the production of proinflammatory cytokines through inhibiting the activation of TLR2/MyD88 signaling pathway. The gene discussed is TLR2; the disease is atherosclerosis.