The results are consistent with the findings by Chen et al. (2017) that infection of S. japonicum stimulated the differentiation of Tregs and our previous findings of the therapeutic effects of rSj-Cys on sepsis related to the increased levels of IL-10 and TGF-β (Li et al., 2017; Xie et al., 2021). The gene discussed is IL10; the disease is Sepsis.