In esophageal squamous cell carcinoma (ESCC), differentially methylated CpG sites between cancer tissue and healthy tissue were found in genes in the IL10 signaling pathway; IL-6 was found to be hypomethylated, while IL-1α was found to be hypermethylated (Lima et al., 2011). Here, IL1A is linked to esophageal squamous cell carcinoma.