Further expression of PD-L1, a T-cell inhibitory receptor ligand causing immunosuppression, was upregulated in pancreatic cancer due to upregulation of H3K27me3 levels in CD274 promoter triggered by KMT2A overexpression (Winograd et al., 2015; Lu et al., 2017). The gene discussed is CD274; the disease is familial pancreatic carcinoma.