IL1B and gastric cancer: In gastric cancer, H. pylori and Epstein-Barr virus (EBV)-induced chronic inflammation is known to induce aberrant methylation in the gastric mucosa, resulting in gene profile changes that promote tumorigenesis, including changes in the expression of target genes such as p16INK4A, LOX, CDH1, IL-1β, IL-8, NOS2, and TNF (Matsusaka et al., 2014).