A study by Tekpli et al., has shown that pro-inflammatory IL-1β, IL-6, and IL-8 genes all show differential DNA methylation patterns in NSCLC when compared to adjacent non-cancerous tissue or bronchial epithelial cells, and there is an inverse relationship between DNA methylation and gene transcription for IL6 and IL1β. The gene discussed is IL6; the disease is non-small cell lung carcinoma.