Co-culturing SPC-A1 lung cancer cells and healthy CD4+ T cells induced DNMT expression and IFNγ promoter hypermethylation in CD4+ T cells, indicating a tumor-induced, DNA methylation-dependent suppression of IFNγ in lung cancer and highlighting the crosstalk between these processes (Wang F. et al., 2013). Here, CD4 is linked to lung carcinoma.