Previous studies show that in prostate cancers, TGF-β promotes H3K4me3 and Retinoblastoma binding protein 5 (RbBP5) recruitment to the Snail promoter by association with Smad2/3 and CBP, leading to enhanced Snail expression in the cancer cells (Li et al., 2016). This evidence concerns the gene SNAI1 and Familial prostate cancer.