TGFB1 and neoplasm: Zhuang et al. (2017) has proved that the dysregulated lncRNA-LET/NF90/miR-145 axis by gemcitabine-induced TGF-β1 promotes UBC chemoresistance through enhancement of cancer cell stemness. Therefore, the discovery of which specific miRNA or which group was essential, which could provide new solutions for clinical tumor diagnosis and gene therapy. Due to the ALDH+ cells that have the characteristics of stem cells, we think that the biological trait of drug resistance may be closely related to the regulation disorder of miRNAs.