Since TNFR2 is highly expressed in tumor infiltrating Tregs and tumor cells (Chang et al., 2015; Chen and Oppenheim, 2017; Zhao et al., 2017), TNFR2 antagonist or other agents blocking TNFR2 expression could exert an antitumor effect. This evidence concerns the gene TNFRSF1B and neoplasm.