Previous studies indicate that the high expression level of TNFR2 could maintain the activity of tumor-infiltrating Tregs in melanoma (Chopra et al., 2013) and promote the expansion of Tregs in liver cancer and ovarian cancer (Chang et al., 2015; Chen and Oppenheim, 2017). The gene discussed is TNFRSF1B; the disease is ovarian carcinoma.