TNFR2 has been implicated in promoting the progression of different types of tumors such as breast cancer (Rivas et al., 2008) and colon cancer (Yang et al., 2015; Torrey et al., 2017), as well as driving the proliferation of tumor stem cells and accelerating metastasis in renal cancer (Al-Lamki et al., 2010, 2016). Here, TNFRSF1B is linked to malignant colon neoplasm.