Although the molecular mechanism by which anti-TNFR2 antibody affects tumor cells is unclear, previous studies suggest that TNFR2 signaling promotes the cell proliferation by activating PI3K/Akt or NF-κB signaling (Rodríguez et al., 2011; Okubo et al., 2013; Chang et al., 2015). This evidence concerns the gene AKT1 and neoplasm.