In the current research, we quantified the HUWE1 mRNA and protein levels in CD4+ T cells in peripheral blood from ITP patients and assessed the correlation between HUWE1 mRNA level and Treg cell percentage; and analyzed how HUWE1 regulated Treg cell number and its immunosuppressive function. The gene discussed is HUWE1; the disease is autoimmune thrombocytopenic purpura.