BCL2 and neoplasm: Zhang et al. (2021) developed mitochondria-targeting nanomicelles containing BIIB021 (named PEG-IR780-BIIB021), which could not only selectively accumulate in tumors without damaging the surrounding normal tissues but also exhibit strong mild-temperature photothermal therapy without tumor thermal resistance under laser irradiation in MCF-7 cell-bearing mice by regulating Cyt-C, Bcl-2, caspase-9, and Bax.