ACSF3 and infection: ACSF3 variants that were only reported in patients with benign manifestations include c.689G> A, c.1456G> A, c.473C> T, c.1447A> G, c.311A> T, c.1239+2T> G, c.1446_1447delCA, c.424C> T, c.820C> T, c.1553C> A, c.774_775del, and c.1081G> A. Patients carrying these variants were asymptomatic or had infection-induced symptoms that disappeared after treatment (2, 4–9).