The objective of this study was to investigate the short-term effects of switching to semaglutide from other GLP-1 RAs.<h4>Methods</h4>This retrospective cohort study evaluated patients with type 2 diabetes who were initiated on or were switched to semaglutide due to poor diabetes control with other GLP-1 RAs or other medications, or obesity. This evidence concerns the gene GLP1R and obesity disorder.