GCG and Hypoglycemia: An internal Safety Monitoring Committee will be notified of severe adverse events (e.g., severe hypoglycaemia [BG value ≤ 3.9 mmol/L and resulting in loss of consciousness, a call for an ambulance and/or admission to hospital, or use of glucagon], DKA [being unwell due to hyperglycaemia and high ketones, and requiring a visit to the doctor, emergency room, or admission to hospital]) immediately after being reported to research staff.