ACLY and hepatocellular carcinoma: In MHCC97-H cells (a typical HCC cell line with a high level of endogenous SREBP-1), SI-1 could inhibit SREBP-1 activation in a dose-dependent manner: SI-1 inhibited mRNA expression of the downstream genes of SREBP-1 (ACC, ACLY, FASN and ACS) (Table 2).