TNF and familial pancreatic carcinoma: As for TNF-α 308G/A gene polymorphism in pancreatic cancer patients, the heterozygous GA genotype was frequently distributed (49%) in the cachectic group, whereas the wild homozygous GG genotype was frequently distributed (62%) among the non-cachectic group, and the homozygous AA genotype was more frequently distributed in cachectic (15%) than non-cachectic (5%) patients with pancreatic cancer.