In alignment, our results revealed that in the NSCL cancer patients, the homozygous CC genotype of TNF-α 1031T/C constitutes 45% of the cachectic patients, 33% for the heterozygous TC, and 22% for the homozygous TT genotype, contrary to pancreatic cancer patients where the homozygous TT is the most frequent genotype constituting 63% of the cachectic patients, followed by the homozygous CC genotype constituting 20% of cachectic patients and 17% for the heterozygous TC. This evidence concerns the gene TNF and cancer.