BRAF and neoplasm: Moreover, because ATC are such rare disease that patients are unlikely to purchase targeted drugs only for ATC, BRAF-targeted drugs approved for other common diseases imply an important clinical value in ATC treatment (11, 13, 35, 50).Recent citations noted anaplastic foci and blood BRAF. Compared to traditional traumatic diagnostic methods to recognize anaplastic foci, circulating cell-free DNA (cfDNA) in peripheral blood has become a potential candidate as biomarker in early tumor detection for its convenience and non-invasion (51, 52).