In the phase 3 BROCADE3 trial (N = 509), addition of veliparib to carboplatin and paclitaxel resulted in a significant improvement in median PFS compared with placebo plus carboplatin and paclitaxel (14.5 vs. 12.6 months; HR: 0.71, 95% CI: 0.57–0.88; p = 0.002) in patients with gBRCA-mutated, HER2-negative, locally advanced or metastatic BC (105, 106). Here, ERBB2 is linked to breast cancer.