In the phase II KEYNOTE-021 trial, data from Cohort G showed that first-line pembrolizumab combined with chemotherapy provided a higher ORR (58% vs. 33%) and longer PFS (median, 24.5 vs. 9.9 months), and a long-term follow up (median 49.4 months) revealed a longer OS (median, 34.5 vs. 21.1 months; HR, 0.71; 95% CI, 0.45‒1.12), versus chemotherapy alone in patients with advanced EGFR/ALK wild-type, nonsquamous NSCLC (80–82). This evidence concerns the gene ALK and non-small cell lung carcinoma.