CD274 and non-small cell lung carcinoma: ORIENT-11 (NCT03607539) was a randomized, double-blind, phase III study investigating the use of sintilimab combined with pemetrexed and platinum chemotherapy in patients with locally advanced or metastatic nonsquamous NSCLC; patients were stratified by PD-L1 expression (TPS ≥ 1% or < 1%).