CD274 and non-small cell lung carcinoma: The subsequent randomized phase III trial KEYNOTE-024 showed that, compared with platinum-based chemotherapy, first-line treatment with pembrolizumab provided better progression-free survival (PFS), OS, and objective response rate (ORR) in previously untreated patients with metastatic, PD-L1-high (TPS ≥ 50%) NSCLC (median PFS, 10.3 vs. 6.0 months; median OS, 26.3 vs. 13.4 months; ORR, 44.8% vs. 27.8%; updated 5-year OS rate, 31.9% vs. 16.3%) (60, 61).