Given the use of pembrolizumab as first-line treatment for certain patients with NSCLC, PD-L1 expression testing and EGFR/ALK status testing are recommended at the first diagnosis of patients with advanced NSCLC in China, according to the 2020 Chinese Society of Clinical Oncology (CSCO) guidelines (55, 56). This evidence concerns the gene CD274 and non-small cell lung carcinoma.