CASP3 and colorectal carcinoma: In addition, we are first to discover that PPM could trigger an increase of expression profile for the pro-apoptotic proteins Bax, cleaved caspase-3, and cleaved caspase-9, and a decrease in those of the anti-apoptotic proteins Bcl-2 and survivin, contributing to increased apoptotic ratio in CRC cell (14, 27).