To further characterize three noncoding hotspot mutations, two not previously reported in BAD and DHODH and one in CHCHD2 previously reported in melanoma (74), we analyzed their potential impact with a number of computational tools and investigated their incidence in other cancers using external datasets of a large cohort (>10,000 samples) of TCGA samples, representing 33 different human cancer types (including 469 skin cutaneous melanoma (SKCM) samples but not including BCC or SCC samples). Here, BAD is linked to melanoma.