SPHK2 and skin basal cell carcinoma: Among the 5’UTR-drivers, 6 were also identified as frequently mutated: DHODH, CHCHD2, and SPHK2 (described above), as well as POLR2M, NPC1, and NELL2. Additionally, it is worth noting IKBKB (mutated in 3 samples but not reported before as mutated in BCC) shown to act as a tumor suppressor in nonmelanoma skin cancers and noncancerous skin lesions; it was also shown that deletions of the gene lead to skin inflammation, hair follicle disruption, hyperplasia, and SCC development (106–109).