TERT and melanoma: Despite the limited number of studies on noncoding mutations, there are some spectacular examples of noncoding driver mutations, for example, TERT promoter mutations, which occur most frequently in melanoma, brain, and bladder cancers but are also reported in BCC (25–27), and mutations in the precursor of miR-142, which frequently occur in non-Hodgkin lymphomas and acute myeloid leukemia [summarized in (28)].