TOPORS and breast cancer: Among the 11 genes frequently mutated in the 3’UTR (Table S7), in addition to BAD described above (see subsection Hotspot mutations), we also identified 8 mutations in the 3’UTR of SMIM27 (also annotated as lncRNA TOPORS-AS1); the overexpression of SMIM27 was found to be associated with favorable outcomes in breast cancer (97).