SPTLC3 and cancer: The skin/cancer-related genes in the most significant focally amplified regions worth mentioning are STIM2 (chr4p15.2; q=0.16; occurring in 2 samples) (123), KLRB1/CD161 (chr12p13.31; q=0.007; occurring in 2 samples) (124, 125), and SPTLC3 (chr20p12.1 q=0.23; occurring in 2 samples) (126).