BAD and cancer: To further characterize three noncoding hotspot mutations, two not previously reported in BAD and DHODH and one in CHCHD2 previously reported in melanoma (74), we analyzed their potential impact with a number of computational tools and investigated their incidence in other cancers using external datasets of a large cohort (>10,000 samples) of TCGA samples, representing 33 different human cancer types (including 469 skin cutaneous melanoma (SKCM) samples but not including BCC or SCC samples).