NFATC2 and cancer: Analysis of the 5’UTR sequence (80) showed that the double substitution (GG>AA) at the hotspot creates a consensus binding site for the NFAT1 transcription factor (Figure 2B), which is expressed in many tissues, including sun-exposed and non-sun-exposed skin (GTExPortal; GTEx Consortium Science 2020), and implicated in many cancers, including melanoma (81, 82).