The most common TRAEs of any Grade were fatigue (n=14), anorexia (n=8), alanine aminotransferase (ALT) elevation (n=7) or aspartate aminotransferase (AST) elevation (n=7), rash (n=6), hypertension (n=5) and hoarseness (n=5). The gene discussed is GPT; the disease is hypertensive disorder.