After 21 days of treatment, inverse correlations were found between kidney tumor size and circulating % CD4+ T cells in Alphataxin-treated mice (r = −0.80, P=0.05, n=6/arm); circulating % CD8+ T cells in anti-PD-1-treated mice with (r= −0.72, P=0.105); circulating % CD8+ T cells (r = −0.83, P=0.04) in the combination treatment group (Table 3). Here, CD4 is linked to kidney neoplasm.