On the other hand, R-2-hydroxyglutaric acid (R-2HG) can stabilize the expression of MYC/CEBPA mRNA by inhibiting FTO demethylation and blocking mRNA degradation mediated by the m6A binding protein YTHDF2, thus inhibiting the proliferation of AML cells (50). The gene discussed is FTO; the disease is acute myeloid leukemia.