However, even though PcrV treatment did not alter the percentage of TAMs infiltrated in the TME (Supplementary Figure 2G, H), the ratios of M1-polarized TAMs (F4/80+CD11c+CD206−, F4/80+MHCII+, and F4/80+CD86+ macrophages) were increased in PcrV-treated tumor tissues (Figures 2A–D), whereas those of M2-polarized TAMs (F4/80+CD11c−CD206+ macrophages) were decreased (Figures 2A, B). The gene discussed is MRC1; the disease is neoplasm.