P53 suppresses lipid biosynthesis via inhibiting lipogenesis, yet induces fatty acid oxidation as an alternative energy source to glycolysis in the condition of nutritional deficiency (53, 54), implicating p53 as a positive regulator of catabolism (increase fatty acid levels) and an inhibitor of anabolism (decrease fatty acid levels) in the process of fatty acid metabolism. This evidence concerns the gene TP53 and nutritional deficiency disease.