Another study performed in poorly differentiated hepatocellular carcinoma (HCC) showed an association between PI3K/AKT/mTOR signaling pathway activation through the protein 3-phosphoinositide-dependent protein kinase 1 (PDPK1) and an increase in stemness characteristics, EMT, metastasis, DDR, and RR (157). This evidence concerns the gene AKT1 and hepatocellular carcinoma.